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Table 1 Effects of restraint stress (RS) on plasma ACTH and the corticosterone levels of gnotobiotic mice

From: Possible role of the gut microbiota in the pathogenesis of anorexia nervosa

  ACTH (pg/ml) Corticosterone (ng/ml)
Basal 1 h-RS Basal 1 h-RS
GF 66 ± 12 188 ± 16 19 ± 3.9 131 ± 12
SPF 54 ± 6.1 106 ± 20*** 21 ± 6.5 86 ± 9.9***
B. infantis 60 ± 9.8 113 ± 15*** 21 ± 5.2 79 ± 9.5***
B. vulgatus 63 ± 9.9 166 ± 14 17 ± 6.8 140 ± 14
EPEC 49 ± 15 243 ± 22* 19 ± 6.6 172 ± 20*
ΔTir 60 ± 9.5 153 ± 25 15 ± 3.6 102 ± 17
  1. Plasma ACTH and corticosterone levels were measured before or immediately after 1 h of RS in germ-free (GF), specific-pathogen-free (SPF), and gnotobiotic mice reconstituted with a single strain with Bifidobacterium infantis (B. infantis), Bacteroides vulgatus (B. vulgatus), rabbit-derived enteropathogenic E-coli (EPEC), or EPEC mutant strain (ΔTir) at 9 wks of age, as described previously [30]. *** P < 0.001 and * P < 0.05 (significantly different from the GF value)