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Table 1 Effects of restraint stress (RS) on plasma ACTH and the corticosterone levels of gnotobiotic mice

From: Possible role of the gut microbiota in the pathogenesis of anorexia nervosa

 

ACTH (pg/ml)

Corticosterone (ng/ml)

Basal

1 h-RS

Basal

1 h-RS

GF

66 ± 12

188 ± 16

19 ± 3.9

131 ± 12

SPF

54 ± 6.1

106 ± 20***

21 ± 6.5

86 ± 9.9***

B. infantis

60 ± 9.8

113 ± 15***

21 ± 5.2

79 ± 9.5***

B. vulgatus

63 ± 9.9

166 ± 14

17 ± 6.8

140 ± 14

EPEC

49 ± 15

243 ± 22*

19 ± 6.6

172 ± 20*

ΔTir

60 ± 9.5

153 ± 25

15 ± 3.6

102 ± 17

  1. Plasma ACTH and corticosterone levels were measured before or immediately after 1 h of RS in germ-free (GF), specific-pathogen-free (SPF), and gnotobiotic mice reconstituted with a single strain with Bifidobacterium infantis (B. infantis), Bacteroides vulgatus (B. vulgatus), rabbit-derived enteropathogenic E-coli (EPEC), or EPEC mutant strain (ΔTir) at 9 wks of age, as described previously [30]. *** P < 0.001 and * P < 0.05 (significantly different from the GF value)
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BioPsychoSocial Medicine

ISSN: 1751-0759

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