- Case report
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A case report of brief psychotic disorder with catalepsy associated with sequential life-threatening events in a patient with advanced cancer
BioPsychoSocial Medicinevolume 11, Article number: 10 (2017)
Cancer is commonly perceived as life-threatening and universally stressful; however, brief psychotic disorder, which occurs in response to extremely stressful events, has not been reported.
A 63-year-old woman, who was diagnosed as having pancreatic cancer with liver metastasis, became unresponsive with very little reaction to verbal contact after sequential life-threatening events, such as thrombosis of both pulmonary arteries and stenosis of the third portion of the duodenum, due to disease progression over 3 weeks beginning with oncological emergency hospital admission. Laboratory findings and electroencephalography were unremarkable. She maintained the position when the psycho-oncologist raised her hand (catalepsy). She had no medical history of psychiatric illness, or alcohol or drug abuse. From these findings, she was suspected of having a brief psychotic disorder with catalepsy and substupor, and 2.5 mg of haloperidol was administered. Her psychiatric symptoms disappeared in 4 days and the diagnosis of brief psychotic disorder was confirmed.
Brief psychotic disorders can manifest in patients with cancer. Careful clinical assessment is needed to correctly diagnose patients with cancer who develop brief psychotic disorders and to identify those who will benefit from correct treatment.
Cancer is commonly perceived as life-threatening and universally stressful [9, 10], and such perceptions are associated with the pathogenesis of psychiatric disorders and physical illness. The prevalence of psychiatric disorders is high among patients with cancer during both treatment and the terminal stages [3, 7]. The rates of death due to cardiovascular diseases and suicide after receiving cancer diagnosis are also high compared with the general population .
Brief psychotic disorders include those that occur in response to extremely stressful events, which are defined as lasting from 1 day to 1 month followed by a full return to premorbid levels of functioning . However, no patients with cancer who developed brief psychotic disorder have been reported to date.
Here, we describe a patient who developed a brief psychotic disorder after being diagnosed with advanced pancreatic cancer and then experienced sequential life-threatening events soon thereafter.
A 63-year-old woman with advanced pancreatic cancer was referred for a psycho-oncology consultation due to her response, which seemed like sudden onset of loss of consciousness.
On visiting her, we found her bedridden, staring at the ceiling without blinking, and responding minimally but correctly to our questions, including orientation-related ones such as date and location. Her family said that she suddenly became absentminded and stated to her husband, “It is over and I will probably die soon.”
Her clinical findings were as follows: blood pressure, 109/70 mmHg; heart rate, 78 beats/min; oxygen saturation, 98%; body temperature, 36.7 °C. Laboratory findings revealed that alkaline phosphatase and amylase values were slightly increased, but these could not explain her psychiatric symptoms. By electroencephalography, the basic rhythm was 8–10 Hz and slow waves were not evident, findings that did not suggest reduced consciousness. Neurological examination demonstrated that she maintained the position when the psycho-oncologist raised her hand (catalepsy).
She had no medical history of psychiatric illness or alcohol or drug abuse, and she was very kind to others. Her husband said that she was very shocked at her diagnosis of pancreatic cancer, and became anxious about treatment and admission to hospital. She had been afraid of cancer because her grandfather had died of cancer after a long period of suffering.
She had been diagnosed with advanced pancreatic cancer accompanied by multiple liver metastasis 4 months before the event, and gemcitabine was administered. Three weeks before the event she had been admitted to our emergency department with thrombosis of both pulmonary arteries and stenosis of the third portion of the duodenum due to disease progression. She frequently vomited. Insomnia and anxiety reappeared, and after much agonizing, she decided to undergo a gastrointestinal bypass. The surgery proceeded 3 days before the event, without complication and post-operative delirium was not evident.
Based on physical, neurological, and psychiatric assessment, we suspected brief psychotic disorder with catalepsy and substupor, and she was administered 2.5 mg of intravenous haloperidol.
On the following day, she could sit on the bed and respond to our questions more clearly. Two days later, she was able to make expressions and smiled at us. The symptoms disappeared 4 days later and did not reappear. One week later, she told us about this experience and said that it was very scary. We diagnosed a brief psychotic disorder based on these findings, and its features fulfilled the Diagnostic and Statistical Manual of Mental Disorders 5th edition .
Discussion and Conclusions
We described a patient with cancer who developed a brief psychotic disorder that was correctly diagnosed after a detailed clinical examination. We believe that being diagnosed with unresectable pancreatic cancer and soon after experiencing a life-threatening pulmonary artery embolism and small intestinal obstruction were related to the pathogenesis of the disorder.
Correct diagnosis is very important because a misdiagnosis could result in a change in treatment and irrelevant medication being administered, which would increase the possibility of drug-related adverse events [6, 11].
Several differential diagnoses were considered for this patient. Delirium was considered because of her poor response. This frequently develops after surgery  and in patients with advanced cancer . However, we could not find any indicators of delirium; catalepsy is not considered as a symptom of delirium. Furthermore, the basic EEG rhythm ruled out delirium.
Another differential diagnosis was schizophrenia because the patient developed catatonia, which sometimes occurs in patients with schizophrenia . However, she did not have a history of schizophrenia and did not develop any other symptoms that are characteristic of this condition.
Although cancer is commonly perceived as a life-threatening, universally stressful event [9, 10], associations with brief psychotic disorders have not been reported to date. We believe that this disorder is misdiagnosed or underestimated. Detailed clinical observation is likely to uncover new patients.
In conclusion, brief psychotic disorders can manifest in patients with cancer. Careful clinical assessment is needed to correctly diagnose patients with cancer who develop brief psychotic disorders and to identify those who will benefit from correct treatment.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders 5th edidion. Washington DC: American Psychiatric Publishing; 2013.
Chalasani P, Healy D, Morriss R. Presentation and frequency of catatonia in new admissions to two acute psychiatric admission units in India and Wales. Psychol Med. 2005;35:1667–75.
Derogatis LR, Morrow GR, Fetting J, Penman D, Piasetsky S, Schmale AM, et al. The prevalence of psychiatric disorders among cancer patients. JAMA. 1983;249:751–7.
Dyer CB, Ashton CM, Teasdale TA. Postoperative delirium. A review of 80 primary data-collection studies. Arch Intern Med. 1995;155:461–5.
Fang F, Fall K, Mittleman MA, Sparen P, Ye W, Adami HO, et al. Suicide and cardiovascular death after a cancer diagnosis. N Engl J Med. 2012;366:1310–8.
Inouye SK, Marcantonio ER, Metzger ED. Doing Damage in Delirium: The Hazards of Antipsychotic Treatment in Elderly Persons. Lancet Psychiatry. 2014;1:312–5.
Minagawa H, Uchitomi Y, Yamawaki S, Ishitani K. Psychiatric morbidity in terminally ill cancer patients. A prospective study. Cancer. 1996;78:1131–7.
Morita T, Tei Y, Tsunoda J, Inoue S, Chihara S. Underlying pathologies and their associations with clinical features in terminal delirium of cancer patients. J Pain Symptom Manag. 2001;22:997–1006.
Razavi D, Stiefel F. Common psychiatric disorders in cancer patients. I. Adjustment disorders and depressive disorders. Support Care Cancer. 1994;2:223–32.
Stiefel F, Razavi D. Common psychiatric disorders in cancer patients. II. Anxiety and acute confusional states. Support Care Cancer. 1994;2:233–7.
Strawn JR, Keck Jr PE, Caroff SN. Neuroleptic malignant syndrome. Am J Psychiatry. 2007;164:870–6.
This case report was not supported by any funding.
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All authors analyzed and interpreted the patient data regarding her psychiatric disorder. MI was a major contributor in writing the manuscript. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
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