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Table 1 Eligibility criteria for participants

From: A multi-center, randomized, parallel-group study to compare the efficacy of enhanced cognitive behavior therapy (CBT-E) with treatment as usual (TAU) for anorexia nervosa: study protocol

Inclusion criteria

• Those who meet the criteria of DSM-5 for AN.

• Those who are 16 years old or older when they give consent to participate in the study.

• Those whose BMI are equal to or above 14.0 and below 18.5.

• Those living in Japan who are literate in Japanese.

• Those who understand the study concepts and give written informed consent.

Exclusion criteria

• Those who are receiving or have received any type of structured psychotherapies including CBT-E, Family therapy, Maudsley Model of Anorexia Nervosa Treatment for Adults (MANTRA), Specialist Supportive Clinical Management (SSCM), Interpersonal Therapy (IPT) within the last year.

• Those who have mental illnesses* including schizophrenia, bipolar disorder or substance use disorder, or somatic disease that impedes the study treatment.

• Those who are currently receiving antipsychotic medication except for antidepressants, anxiolytics, or hypnotics (The participants on antidepressants or hypnotics will not be excluded as far as they are on stable or reducing dose during the study).

• Those who have an intellectual disability.

• Those who have suicidal ideation.

• Those who are pregnant or might become pregnant.

• Those who have difficulty in attending therapy on schedule.

• Those whom therapists or physicians consider as ineligible to participate in this study.

  1. *: The Structured Clinical Interview for DSM-5, Research Version (SCID-5-RV), is used to exclude patients with any history of schizophrenia, bipolar disorder, or substance use disorder