Fig. 1

Flow diagram of the participants. CBT-E: Enhanced cognitive behavioral therapy, TAU: treatment as usual. T0: baseline, T1: week 20, T2: end of treatment, week 40, T3: follow-up, 6 months after T3. SCID-5 RV: Structured Clinical Interview for DSM-5 Disorders, Research Version, EDE-Q: The Eating Disorder Examination Questionnaire, CIA: Clinical Impairment Assessment questionnaire. The number and frequency of sessions of CBT-E vary according to baseline BMI shown in the Supplementary Table S1. The treatment period and intensity of the TAU are not specifically determined in advance. When participants are remitted at the interim assessment (T1), the study treatment will be terminated. Remission was defined as BMI ≥ 18.5 and the EDE-Q-J global score below 1 stand deviation above the community mean