Fig. 6

Mitochondrial Resilience and Adaptation. Developmental detrimental embedding may handicap mitochondrial resilience and adaptive capacity while protective embedding will enhance them. Persistent stress activation leads to mitochondrial allostatic load (MAL), which is then transmitted via molecular signals into cellular physiology changes resulting in overall allostatic load (AL). Energy ramifications of these micro-physiological states will be influential all the way up the line at the level of the organism’s macro-system health and social performance. Picard and McEwen, 2018, p. 31, [85]. "Reprinted from Psychosomatic Medicine, Feb/Mar; 80(2). Picard M, McEwen BS. Psychological Stress and Mitochondria: A Conceptual Framework. P. 31, 2018, with permission from the author via STM guidelines"