Clinical effects of wasabi extract containing 6-MSITC on myalgic encephalomyelitis/chronic fatigue syndrome: an open-label trial

Table 5 Changes in neurocognitive symptoms and TMT-A test scores after 6-MSITC treatment

	Descriptive	Pre	Post	Δ	P	ES
Subjective
Brain fog	Severity	5.7 ± 1.6	4.5 ± 1.9	-1.1 ± 1.5	0.011^b	0.75
Difficulty finding words	Severity	4.8 ± 2.1	3.7 ± 1.7	-1.1 ± 1.5	0.015^b	0.72
Memory loss	Severity	4.0 ± 2.3	3.6 ± 1.8	-0.4 ± 2.1	0.479^b	0.19
Photophobia	Yes/No (n)	13/2	11/4		0.157^a	0.36
Photophobia	Severity	4.8 ± 2.9	3.5 ± 3.4	-1.3 ± 1.6	0.008^b	0.8
Cognitive test
TMT-A	Time (sec)	53.0 ± 16.3	38.1 ± 13.8	-14.9 ± 18	0.007^b	0.82

Δ: differences between scores before and after treatment (subtraction of Pre from Post). ES: effect sizes were calculated using the Cramer’s V or Cohen’s d as appropriate. P: p values were analyzed using ^a a paired samples McNemar’s test and ^b a parametric paired Student’s t-test. Severity was described using a numerical rating scale, with 10 being the worst and 0 being none. Frequency: days per week; n Number; TMT-A Trail Making test-A; (n = 15)

ISSN: 1751-0759