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Table 4 Changes in pain symptoms and pressure pain thresholds after 6-MSITC treatment

From: Clinical effects of wasabi extract containing 6-MSITC on myalgic encephalomyelitis/chronic fatigue syndrome: an open-label trial

 

Descriptive

Pre

Post

Δ

P

ES

Symptoms

 Headache

Yes/No (n)

13/2

12/3

 

0.317a

0.26

Frequency

4.1 ± 2.6

3.0 ± 2.3

-1.1 ± 1

0.001b

1.03

Severity

5.3 ± 2.8

4.5 ± 3.3

-0.8 ± 2

0.145b

0.4

 Myalgia

Yes/No (n)

12/3

10/5

 

0.157a

0.36

Frequency

4.1 ± 2.7

2.4 ± 2.5

-1.7 ± 2.4

0.019b

0.68

Severity

4.9 ± 3.7

3.5 ± 3.4

-1.4 ± 2.7

0.061b

0.52

 Arthralgia

Yes/No (n)

11/4

7/8

 

0.157a

0.36

Frequency

3.9 ± 4.6

2.3 ± 2.9

-1.6 ± 3.4

0.091b

0.47

Severity

4.0 ± 3.6

2.8 ± 3.4

-1.2 ± 3.2

0.164b

0.38

 Pharyngeal pain

Yes/No (n)

9/6

9/6

 

1a

0

Frequency

2.1 ± 2.4

1.9 ± 2.3

-0.1 ± 2.0

0.803b

0.07

Severity

2.5 ± 2.6

2.5 ± 2.5

-0.1 ± 1.9

0.892b

0.04

PPT (kPa)

Right occipital

17.3 ± 10.6

21.3 ± 10.6

4.0 ± 5.2

0.01b

0.77

Left occipital

18.8 ± 12.3

19.7 ± 11.5

0.9 ± 7.4

0.633b

0.13

  1. Δ: differences between scores before and after treatment (subtraction of Pre from Post). ES: effect sizes were calculated using the Cramer’s V or Cohen’s d as appropriate. P: p values were analyzed using a a paired samples McNemar’s test and b a parametric paired Student’s t-test. Severity was described using a numerical rating scale, with 10 being the worst and 0 being none. Frequency: days per week; n Number; PPT Pressure pain threshold of the right and left occipital regions; (n = 15)