Week 4 | Week 8 | Week 12 | Last point | |||||
---|---|---|---|---|---|---|---|---|
Placebo | Ramosetron | Placebo | Ramosetron | Placebo | Ramosetron | Placebo | Ramosetron | |
5 μg | 5 μg | 5 μg | 5 μg | |||||
Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | |
P value | P value | P value | P value | P value | P value | P value | P value | |
N | 48 | 46 | 49 | 44 | 47 | 44 | 50 | 47 |
Overall scores | −75.0 ± 81.52 | −95.9 ± 105.12 | −103.0 ± 81.81 | −130.6 ± 114.27 | −110.3 ± 97.04 | −137.0 ± 113.18 | −108.2 ± 94.44 | −133.5 ± 110.72 |
P = 0.283 | P = 0.181 | P = 0.231 | P = 0.228 | |||||
Severity of abdominal pain | −15.3 ± 25.18 | −17.0 ± 25.15 | −21.4 ± 28.46 | −24.3 ± 27.41 | −21.9 ± 30.42 | −26.6 ± 27.01 | −21.9 ± 29.76 | −26.1 ± 26.41 |
P = 0.743 | P = 0.625 | P = 0.439 | P = 0.467 | |||||
Frequency of abdominal pain | −16.5 ± 25.89 | −20.0 ± 32.52 | −24.7 ± 29.38 | −26.6 ± 35.04 | −25.1 ± 32.56 | −28.2 ± 35.13 | −24.6 ± 31.77 | −28.1 ± 33.98 |
P = 0.560 | P = 0.777 | P = 0.666 | P = 0.603 | |||||
Intensity of abdominal distension | −9.7 ± 23.13 | −16.3 ± 27.68 | −12.2 ± 24.54 | −17.8 ± 26.66 | −11.5 ± 25.83 | −16.6 ± 29.88 | −10.8 ± 25.26 | −16.3 ± 29.22 |
P = 0.214 | P = 0.295 | P = 0.385 | P = 0.325 | |||||
Dissatisfaction with bowel habits | −16.2 ± 31.23 | −20.8 ± 28.18 | −19.2 ± 33.55 | −31.4 ± 29.88 | −25.1 ± 33.57 | −33.4 ± 31.50 | −24.8 ± 33.84 | −32.5 ± 30.63 |
P = 0.454 | P = 0.067 | P = 0.230 | P = 0.243 | |||||
Interference with QOL | −17.3 ± 27.76 | −21.8 ± 29.94 | −25.5 ± 27.75 | −30.5 ± 34.84 | −26.7 ± 28.67 | −32.2 ± 32.53 | −26.1 ± 28.04 | −30.6 ± 32.44 |
P = 0.454 | P = 0.445 | P = 0.396 | P = 0.470 |