Skip to main content

Table 2 Transplantation of normal gut microbiota renders germ-free (GF) mice less active and anxious

From: Possible role of the gut microbiota in the pathogenesis of anorexia nervosa

  7 wks of age 10 wks of age 16 wks of age
GF OFT (DT30) 62.7 ± 12.2 63.7 ± 9.4 66.4 ± 21.4
MBT (NBM) 14.3 ± 5.3 15.9 ± 5.9 14.6 ± 6.2
EX-GF OFT (DT30) 46.5 ± 7.1*** 54.0 ± 8.9** 53.5 ± 11.3*
MBT (NBM) 12.5 ± 5.8 12.4 ± 4.5* 9.5 ± 5.5*
  1. Parent GF mice were transplanted with feces of SPF mice, and their offspring were used as EX-GF mice, as previously described [35]. GF and EX-GF mice at 7, 10 and 16 wks of age were subjected to the open-field test (OPT) and marble-burying test (MBT). The total distance traveled for 30 min (DT30; meter) was automatically calculated as spontaneous locomotor activity. The number of marbles buried for 30 min (NBM) was counted as a parameter of anxiety-like behavior. All data are expressed as mean ± SD. *p < 0.05, **p < 0.01 and ***p < 0.001 (significantly different from the corresponding GF value)