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Table 2 Results related to the changes of IBS-SSS total score, IBS-SSS sub-scale scores, IBS-QoL score, and HADS score over time in the two groups

From: A randomized, double-blind, placebo-controlled study to assess efficacy of mirtazapine for the treatment of diarrhea predominant irritable bowel syndrome

Variable

Group

Baseline

Week 8

Mean difference

Total IBS-SSS score

Intervention

301.68 ± 78.73

211.92 ± 62.72

− 89.76 ± 71.60

Control

294.09 ± 71.55

259.36 ± 72.81

− 34.73 ± 66.91

P- value

0.68

0.006

0.002

IBS-SSS Pain severity score

Intervention

68.53 ± 18.93

41.47 ± 17.08

− 27.06 ± 18.83

Control

61.18 ± 15.71

52.53 ± 16.40

−9.00 ± 14.87

P- value

0.10

0.009

< 0.001

IBS-SSS Pain frequency score

Intervention

60.59 ± 20.59

42.06 ± 19.81

−18.52 ± 16.54

Control

60.24 ± 14.06

54.21 ± 14.18

−6.03 ± 15.82

P- value

0.94

0.005

0.002

IBS-SSS abdominal distention severity score

Intervention

61.76 ± 22.35

50.29 ± 18.50

−11.47 ± 12.34

Control

61.43 ± 16.96

53.58 ± 16.86

−7.84 ± 16.41

P- value

0.91

0.45

0.31

IBS-SSS bowel habit dissatisfaction score

Intervention

58.53 ± 22.85

39.41 ± 15.94

−19.12 ± 21.08

Control

58.06 ± 18.03

51.21 ± 17.98

−6.97 ± 14.68

P- value

0.84

0.006

0.008

IBS-SSS life interference score

Intervention

51.47 ± 21.90

37.65 ± 18.60

−13.82 ± 15.18

Control

54.09 ± 18.69

48.79 ± 18.50

−5.30 ± 12.12

P- value

0.60

0.01

0.02

HADS-A

Intervention

9.36 ± 3.26

5.57 ± 1.89

−3.70 ± 3.48

Control

8.88 ± 2.33

7.19 ± 2.65

−1.69 ± 2.79

P- value

0.59

0.005

0.01

HADS-D

Intervention

8.15 ± 2.99

5.97 ± 1.58

−2.18 ± 3.74

Control

7.73 ± 2.77

6.88 ± 2.52

−0.85 ± 3.23

P- value

0.55

0.08

0.13

IBS-QoL

Intervention

45.32 ± 17.18

70.52 ± 16.55

25.19 ± 15.60

Control

53.11 ± 16.34

62.68 ± 14.25

9.56 ± 14.89

P- value

0.06

0.04

< 0.001

  1. IBS-SSS IBS Severity Scoring System, IBS-QoL IBS Quality of Life, HADS Hospital Anxiety and Depression Scale questionnaire