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Table 2 Results related to the changes of IBS-SSS total score, IBS-SSS sub-scale scores, IBS-QoL score, and HADS score over time in the two groups

From: A randomized, double-blind, placebo-controlled study to assess efficacy of mirtazapine for the treatment of diarrhea predominant irritable bowel syndrome

Variable Group Baseline Week 8 Mean difference
Total IBS-SSS score Intervention 301.68 ± 78.73 211.92 ± 62.72 − 89.76 ± 71.60
Control 294.09 ± 71.55 259.36 ± 72.81 − 34.73 ± 66.91
P- value 0.68 0.006 0.002
IBS-SSS Pain severity score Intervention 68.53 ± 18.93 41.47 ± 17.08 − 27.06 ± 18.83
Control 61.18 ± 15.71 52.53 ± 16.40 −9.00 ± 14.87
P- value 0.10 0.009 < 0.001
IBS-SSS Pain frequency score Intervention 60.59 ± 20.59 42.06 ± 19.81 −18.52 ± 16.54
Control 60.24 ± 14.06 54.21 ± 14.18 −6.03 ± 15.82
P- value 0.94 0.005 0.002
IBS-SSS abdominal distention severity score Intervention 61.76 ± 22.35 50.29 ± 18.50 −11.47 ± 12.34
Control 61.43 ± 16.96 53.58 ± 16.86 −7.84 ± 16.41
P- value 0.91 0.45 0.31
IBS-SSS bowel habit dissatisfaction score Intervention 58.53 ± 22.85 39.41 ± 15.94 −19.12 ± 21.08
Control 58.06 ± 18.03 51.21 ± 17.98 −6.97 ± 14.68
P- value 0.84 0.006 0.008
IBS-SSS life interference score Intervention 51.47 ± 21.90 37.65 ± 18.60 −13.82 ± 15.18
Control 54.09 ± 18.69 48.79 ± 18.50 −5.30 ± 12.12
P- value 0.60 0.01 0.02
HADS-A Intervention 9.36 ± 3.26 5.57 ± 1.89 −3.70 ± 3.48
Control 8.88 ± 2.33 7.19 ± 2.65 −1.69 ± 2.79
P- value 0.59 0.005 0.01
HADS-D Intervention 8.15 ± 2.99 5.97 ± 1.58 −2.18 ± 3.74
Control 7.73 ± 2.77 6.88 ± 2.52 −0.85 ± 3.23
P- value 0.55 0.08 0.13
IBS-QoL Intervention 45.32 ± 17.18 70.52 ± 16.55 25.19 ± 15.60
Control 53.11 ± 16.34 62.68 ± 14.25 9.56 ± 14.89
P- value 0.06 0.04 < 0.001
  1. IBS-SSS IBS Severity Scoring System, IBS-QoL IBS Quality of Life, HADS Hospital Anxiety and Depression Scale questionnaire