Higher galectin-3 levels are independently associated with lower anxiety in patients with risk factors for heart failure

Table 2 Results from multivariate regression models in the Diast-CHF study group with HADS anxiety as the dependent variable

	B	95% confidence interval	β	P value
Model 1: Total model p < 0.001, adjusted R² = 0.115, F = 15.051
Galectin-3	-2.493	-4.354;-0.632	-0.080	0.009
Gender	0.605	0.128;1.082	0.081	0.013
Age	-0.054	-0.091;-0.018	-0.114	0.004
BMI	0.055	-0.114;0.004	-0.071	0.066
eGFR	0.008	-0.004;0.020	0.056	0.214
LVEF	0.021	-0.009;0.050	0.043	0.173
ASE grade	0.136	-0.219;0.490	0.024	0.453
6-min walking distance	0.002	-0.001;0.004	0.059	0.127
SF-36 physical functioning	-0.057	-0.068;-0.045	-0.355	< 0.001
Model 2: Total model p < 0.001, adjusted R² = 0.108, F = 9.483
Galectin-3	-2.413	-4.422;-0.404	-0.077	0.019
Gender	0.249	-0.323;0.821	0.033	0.394
Age	-0.053	-0.094;-0.013	-0.111	0.010
BMI	-0.034	-0.101;0.033	-0.043	0.318
eGFR	-0.002	-0.016;0.012	-0.013	0.809
LVEF	0.007	-0.025;0.039	0.015	0.669
ASE grade	0.200	-0.189;0.589	0.035	0.314
6-min walking distance	0.002	-0.001;0.004	0.044	0.287
SF-36 physical functioning	-0.056	-0.069;-0.043	-0.345	< 0.001
CT-proAVP	-0.913	-1.776;0.050	-0.078	0.038
NT-proBNP	-0.286	-1.212;0.640	-0.034	0.545
MR-proANP	-0.843	-2.665;0.979	0.052	0.364

Results from multivariate linear regression models with HADS anxiety scores as dependent variable and plasma galectin-3 as independent variable adjusted for gender, age, BMI body-mass index, eGFR estimated glomerular filtration rate, LVEF left ventricular ejection fraction, ASE grade American Society of Echocardiography, 6-min walking distance, SF-36 physical functioning and, optionally, CT-proAVP, and natriuretic peptides NT-proBNP and MR-proANP

ISSN: 1751-0759