Table 1 Mean (±SD) values for blood ammonia concentration, VPA doses, and liver function as well as percentage of patients exhibiting clinically significant elevations of the respective laboratory data
constituent | Unit | Total (n = 37) | |||
|---|---|---|---|---|---|
Reference range | Mean ± SD of patients | Below Reference range % | Patients exhibiting values of 1.3-times or greater than the upper limits of the reference range (%) | ||
ammonia | μg/dL | 18-70 | 64 ± 19 | 0 | 30 |
AST | IU/L | 7-38 | 21 ± 7 | 0 | 5 |
ALT | IU/L | 4-44 | 23 ± 15 | 0 | 11 |
VPA concentration | μg/mL | 50-100 | 51 ± 24 | 54 | 5 |