Evaluation of the irritable bowel syndrome severity index in Japanese male patients with irritable bowel syndrome with diarrhea

Ida, Motoko; Nishida, Akito; Akiho, Hiraku; Nakashima, Yoshihiro; Matsueda, Kei; Fukudo, Shin

doi:10.1186/s13030-017-0092-x

Table 3 Change in each IBSSI-J component score from baseline at each evaluation point

From: Evaluation of the irritable bowel syndrome severity index in Japanese male patients with irritable bowel syndrome with diarrhea

	Week 4		Week 8		Week 12		Last point
	Placebo	Ramosetron	Placebo	Ramosetron	Placebo	Ramosetron	Placebo	Ramosetron
	Placebo	5 μg		5 μg		5 μg		5 μg
	Mean ± SD	Mean ± SD	Mean ± SD	Mean ± SD	Mean ± SD	Mean ± SD	Mean ± SD	Mean ± SD
	P value	P value	P value	P value	P value	P value	P value	P value
N	48	46	49	44	47	44	50	47
Overall scores	−75.0 ± 81.52	−95.9 ± 105.12	−103.0 ± 81.81	−130.6 ± 114.27	−110.3 ± 97.04	−137.0 ± 113.18	−108.2 ± 94.44	−133.5 ± 110.72
Overall scores	−75.0 ± 81.52	P = 0.283	−103.0 ± 81.81	P = 0.181	−110.3 ± 97.04	P = 0.231	−108.2 ± 94.44	P = 0.228
Severity of abdominal pain	−15.3 ± 25.18	−17.0 ± 25.15	−21.4 ± 28.46	−24.3 ± 27.41	−21.9 ± 30.42	−26.6 ± 27.01	−21.9 ± 29.76	−26.1 ± 26.41
Severity of abdominal pain	−15.3 ± 25.18	P = 0.743	−21.4 ± 28.46	P = 0.625	−21.9 ± 30.42	P = 0.439	−21.9 ± 29.76	P = 0.467
Frequency of abdominal pain	−16.5 ± 25.89	−20.0 ± 32.52	−24.7 ± 29.38	−26.6 ± 35.04	−25.1 ± 32.56	−28.2 ± 35.13	−24.6 ± 31.77	−28.1 ± 33.98
Frequency of abdominal pain	−16.5 ± 25.89	P = 0.560	−24.7 ± 29.38	P = 0.777	−25.1 ± 32.56	P = 0.666	−24.6 ± 31.77	P = 0.603
Intensity of abdominal distension	−9.7 ± 23.13	−16.3 ± 27.68	−12.2 ± 24.54	−17.8 ± 26.66	−11.5 ± 25.83	−16.6 ± 29.88	−10.8 ± 25.26	−16.3 ± 29.22
Intensity of abdominal distension	−9.7 ± 23.13	P = 0.214	−12.2 ± 24.54	P = 0.295	−11.5 ± 25.83	P = 0.385	−10.8 ± 25.26	P = 0.325
Dissatisfaction with bowel habits	−16.2 ± 31.23	−20.8 ± 28.18	−19.2 ± 33.55	−31.4 ± 29.88	−25.1 ± 33.57	−33.4 ± 31.50	−24.8 ± 33.84	−32.5 ± 30.63
Dissatisfaction with bowel habits	−16.2 ± 31.23	P = 0.454	−19.2 ± 33.55	P = 0.067	−25.1 ± 33.57	P = 0.230	−24.8 ± 33.84	P = 0.243
Interference with QOL	−17.3 ± 27.76	−21.8 ± 29.94	−25.5 ± 27.75	−30.5 ± 34.84	−26.7 ± 28.67	−32.2 ± 32.53	−26.1 ± 28.04	−30.6 ± 32.44
Interference with QOL	−17.3 ± 27.76	P = 0.454	−25.5 ± 27.75	P = 0.445	−26.7 ± 28.67	P = 0.396	−26.1 ± 28.04	P = 0.470

Data are expressed as mean ± standard deviation. P values were calculated using analysis of variance

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ISSN: 1751-0759

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