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Table 1 Beneficial effects of Kampo medicines on mind, stress, and body in functional gastrointestinal disorders

From: Effects of Kampo on functional gastrointestinal disorders

  Effects on brain Effects on stress Effects on GI tract
Rikkunshito Reduces depressive symptoms and high cortisol levels. Inhibits stress-induced activation of HPA axis and SNS. Improves gastric motility dysfunction, i.e., gastric emptying and gastric accommodation.
Reduces anxiety.
Inhibits activities of CRH-producing neurons.   Modulates gastric hypersensitivity.
Increases ghrelin secretion.
Keishikashakuyakuto Has sedative, antidepressant-like effects. Inhibits stress-induced activation of HPA axis. Has anti-spasmodic, anti-inflammatory, and analgesic effects.
  Increases BDNF   
  1. BDNF, brain-derived neurotrophic factor; CRH, corticotropin-releasing hormone; GI, gastrointestinal; HPA, hypothalamic-pituitary-adrenocortical; SNS, sympathetic nervous system.