Skip to main content

Table 4 Changes in plasma IL-6, sIL-6R, and TNF-α concentrations in depressed menopausal patients with undefined symptoms after treatment for three months with Kami-shoyo-san or anti-depressants

From: The role of traditional Japanese medicine (Kampo) in the practice of psychosomatic medicine: the usefulness of Kampo in the treatment of the stress-related symptoms of women, especially those with peri-menopausal disorder

 

Kami-shoyo-san

 

Anti-depressants

Significance

IL-6

     

 % change

−29.1 ± 7.3%

 

8.6 ± 6.5%

 

P < 0.0001

 plasma level

     

  before treatment

1.88 ± 1.56 pg/ml

]*1

2.06 ± 1.99 pg/ml

]*3

NS

  After 3-month treatment

1.20 ± 0.85 pg/ml

2.35 ± 3.79 pg/ml

P = 0.04

sIL-6R

     

 % change

−17.6 ± 4.9%

 

3.4 ± 6.1%

 

P = 0.001

 plasma level

     

  before treatment

104.3 ± 25.5 ng/ml

]*2

99.8 ± 29.5 ng/ml

]*4

NS

  3-months treatment

92.0 ± 33.7 ng/ml

102.4 ± 32.7 ng/ml

NS

TNF-α

     

 % change

21.3 ± 5.4%

 

−6.8 ± 2.2%

 

P < 0.001

 plasma level

     

  before treatment

14.2 ± 6.3 pg/ml

]*5

15.0 ± 6.6 pg/ml

]*6

NS

  3-months treatment

17.2 ± 6.1 pg/ml

14.5 ± 6.0 pg/ml

P < 0.05

  1. *1: P = 0.02, *2: P = 0.02, *3: NS, *4: NS, *5: P < 0.0001, *6: NS.