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Table 1 Bio psycho social origins of chronic diseases (e.g coronary heart disease, bronchial asthma, rheumatoid arthritis, inflammatory bowel disease, essential hypertension, atopic dermatitis, diabetes, cancer and others; modified after Orth-Gomér et al 1997)

From: Psychosocial interventions for patients with chronic disease

Origins of
Disease
Factor 1 Factor 2 Factor 3 Factor 4 Factor 5 Factor 6 Factor 7
Psychological mediators depression anxiety hostility denial type A type C type D
Behavioral risk factors smoking sedentary life style poor nutrition alcohol consumption suicidal behavior no care for the own person over active
Pathological mechanism genetic autonomic im-balance psycho-immunological path-ways psycho-endocrinological path-ways inflammation lipids/
glucose
coagulation
Severity of disease        
somatic bodily complaints bodily limitations pain     
psychological psychic symptoms chronic depression suicidal tenden-cies chronic anxiety too many doctor visits too many drugs social inhibition
sociological low social functioning social isolation unable to work low income high treatment costs