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Table 3 Hemodynamic variables at supine rest and during a 20° head-up tilt-test.

From: Adolescent chronic fatigue syndrome; a follow-up study displays concurrent improvement of circulatory abnormalities and clinical symptoms

 

CFS-patients

Healthy controls (n = 33) †

 

First visit

(n = 38)

Second visit (n = 37)

p-value*

 

Baseline

    

HR (beats/min)

72.6

67.5

0.033

68.3

 

(68.9-76.9)

(63.5-74.0)

 

(65.5-72.4)

SBP (mm Hg)

108.3

98.9

< 0.001

111.1

 

(105.2-116.1)

(95.3-101.9)

 

(107.9-116.0)

MBP (mm Hg)

80.4

74.0

< 0.001

79.8

 

(77.1-84.8)

(70.5-75.6)

 

(77.2-81.7)

DBP (mm Hg)

68.1

59.3

< 0.001

64.6

 

(64.9-73.1)

(57.5-63.5)

 

(62.8-65.9)

TPRI (mm Hg/l/min/m2)

8.4

7.2

0.001

7.4

 

(7.5-9.4)

(6.9-8.2)

 

(6.9-7.7)

LF/HF

0.6

0.4

0.017

0.6

 

(0.4-0.9)

(0.4-0.6)

 

(0.4-1.0)

Response (Tilt--Baseline)

    

Δ HR (beats/min)

5.4

2.3

0.030

0.9

 

(2.5-6.5)

(1.0-3.0)

 

(-0.2-2.2)

Δ SBP (mm Hg)

2.1

1.8

0.531

-0.9

 

(0.9-3.8)

(-0.2-4.0)

 

(-1.8-0.9)

Δ MBP (mm Hg)

4.3

1.6

0.001

0.3

 

(3.2-6.7)

(0.5-3.3)

 

(-1.6-1.7)

Δ DBP (mm Hg)

4.1

1.6

0.001

0.4

 

(3.6-5.8)

(0.3-2.8)

 

(-1.5-2.5)

Δ TPRI (mm Hg/l/min/m2)

1.0

0.7

< 0.001

0.2

 

(0.7-1.6)

(0.3-0.8)

 

(-0.02-0.5)

Δ LF/HF

0.3

0.2

0.187

-0.03

 

(0.1-0.5)

(0.1-0.3)

 

(-0.2-0.1)

  1. Median (confidence intervals)
  2. * Wilcoxon's signed rank test, 2-sided, between first and second visits for the CFS patients. †Although not the primary scope of this article, reference values from healthy control subjects are displayed for clarity. Details concerning this reference material have been described elsewhere [8]. In order to avoid methodological problems of multiple comparisons, statistical tests between patients and control subjects have not been carried out
  3. HR = heart rate; SBP = systolic blood pressure; MBP = mean arterial blood pressure; DBP = diastolic blood pressure; TPRI = total peripheral resistance index; LF/HF = Ratio of low-frequency to high frequency power of heart rate variability
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BioPsychoSocial Medicine

ISSN: 1751-0759

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