Decreased response inhibition in middle-aged male patients with type 2 diabetes

Table 2 Neuropsychological performance of patients and control subjects

	OW patients	NW patients	OW controls	NW controls	DM*	OW*	Interaction*
<Go/NoGo task>
Discriminability (d')	2.66 ± 0.48	2.39 ± 1.0	3.14 ± 0.59	3.28 ± 0.46	0.001^‡	0.648	0.215
Commission errors	9.8 ± 3.8	10.1 ± 3.8	6.6 ± 4.2	5.5 ± 2.9	0.002^‡	0.74	0.463
Omission errors	0.4 ± 0.9	3.8 ± 8.0	0.2 ± 0.4	0.1 ± 0.3	0.049^†	0.081	0.072
RT (ms)	356 ± 28	330 ± 59	339 ± 37	363 ± 35	0.104	0.629	0.009^†
Post-error slowing (ms)	379 ± 66	322 ± 68	348 ± 57	343 ± 40	0.525	0.035^†	0.054
<Reversal and extinction tasks>
Errors after reversal	1.7 ± 3.0	1.2 ± 0.4	1.1 ± 0.3	1.0 ± 0.4	0.977	0.358	0.448
Errors after extinction	7.6 ± 3.7	6.4 ± 4.0	8.7 ± 5.2	5.1 ± 3.0	0.894	0.029^†	0.340
<WCST>
Achievement scores	5.4 ± 1.0	4.6 ± 1.3	5.9 ± 0.6	5.6 ± 0.5	0.218	0.117	0.773
% perseverative errors	2.7 ± 6.4	8.2 ± 10.1	4.2 ± 9.0	3.2 ± 5.3	0.458	0.296	0.147

Neuropsychological data are given as means ± SD. *Data were analysed by covariate analysis of variance (ANCOVA) with age as a covariate, and the main effects and interaction of type 2 diabetes and being overweight are shown as P values. ^†P<0.05, ^‡P < 0.007 with ANCOVA. OW, overweight; NW, normal weight; DM, type 2 diabetes mellitus; RT, reaction time in unplanned responses to the Go stimuli.

ISSN: 1751-0759