Figure 1
From: Symptoms of somatization as a rapid screening tool for mitochondrial dysfunction in depression
Number of "Applies Completely" responses to the six KSP items in Table 1. The hatched area within the left-sloping diagonal bars corresponds to the proposed "normal" range of answering zero or one of the six items as "Applies Completely" (Y axis). The hatched area within the right-sloping diagonal bars corresponds to the range of muscle ATP production rates measured in 10 healthy controls using α-ketoglutarate as substrate (3.9 – 6.5 mmol ATP min-1 kg-1 muscle). α-ketoglutarate predominately stimulates respiration through complex I of the electron transport chain. Complex I deficiency is the most common enzymatic deficiency in the mitochondrial disorders [24].