Effects of antidepressant treatment on heart rate variability in major depression: A quantitative review

van Zyl, Louis T; Hasegawa, Takuya; Nagata, Katsutaro

doi:10.1186/1751-0759-2-12

BioPsychoSocial Medicine

Table 3 Effect Sizes for all measures in all studies examined.

From: Effects of antidepressant treatment on heart rate variability in major depression: A quantitative review

First Author (reference)	N	Design	Recording Time	Drug	Treatment Period (Weeks)	*CB	Effect Size (Cohen's d)
							HR	SDNN	SDANN	RMSSD	LF	ln HF	HF	LF/HF	CV	pNN50
	TCAs Short time recording
Rechlin[55]	24	pre post	5 min	amitriptyline	2	Y	4.43	-1.61		-2.97			-0.87		-9.44
Rechlin [56]	24	pre post	5 min	amitriptyline	2	Y	5.52	-2.59		-2.93			-1.19		-8.85
Rechlin [57]	104	drug vs control	5 min	amitriptyline	1	Y	1.60	-1.53		-1.87			-0.54		-4.76
Rechlin [58]	26	drug vs control	5 min	amitriptyline	2	Y	3.81	-2.55		-3.58			-1.25		-3.97
Rechlin [59]	8	pre post	5 min	amitriptyline	2	Y	6.11	-1.88		-3.66					-10.86
Rechlin [59]	8	pre post	5 min	doxepin	2	Y	7.87	-3.51		-5.04					-21.44
Tulen[9]	9	pre post	8 min	imipramine	4	Y	4.81	-2.44				-6.43			-3.97
Volkers[60]	24	pre post	5 min	imipramine	4	Y	4.52	-3.32				-2.64			-5.52
	TCAs Long time recording
Khaykin[51]	9	pre post	24 h	doxepin	6	N		1.80	3.64	-2.71						-3.34
Lederbogen[50]	14	pre post	24 h	amitriptyline	5	N	1.98	-2.20	-3.01
	SSRIs Short time recording
Rechlin [56]	24	pre post	5 min	paroxetine	2	Y	-0.45	0.05		-0.61			-0.30		-0.09
Rechlin [59]	8	pre post	5 min	fluvoxamine	2	Y	-0.83	0.03		1.47					-0.42
Rechlin [59]	8	pre post	5 min	paroxetine	2	Y	-0.77	0.09		-0.39					-0.27
Straneva-Meuse[61]	17	vs control	2 min	paroxetine	8	N				-1.99
Volkers[60]	17	pre post	5 min	fluvoxamine	4	Y	-0.47					-0.15
	SSRIs Long time recording
Khaykin[51]	5	pre post	24 h	fluoxetine	6	N		2.24	2.81	1.76						1.76
Lederbogen[50]	14	pre post	24 h	paroxetine	5	N	-0.10	-1.21	-1.95
	Other Treatments
Agelink[62]	25	pre-post	5 min	reboxetine	3	Y	1.32			-0.04	-0.38		0.79
Agelink[63]	25	pre-post	5 min	nefazodone	3	Y	-1.60	0.08		0.11	-0.08		-0.20	-0.16	-0.21
Straneva-Meuse[61]	17	vs control	2 min	bupropion	8	N				-1.99
Tulen[9]	8	pre post	8 min	mirtazapine	4	Y	4.81	-2.44				-1.81			-3.97
Karpyak[52]	11	pre post	24 h	ECT	**	NS		0.51								0.90
Nahshoni[53]	10	pre-post	NS	ECT	***	NS					-0.88		0.84

HR = heart rate.
CV = coefficient of variability.
NS = Not Stated.
*CB = Controlled Breathing;.
**ECT performed 3 times per week to a maximum of 10 treatments.
***ECT performed 2 times per week to a maximum of 12 treatments.

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ISSN: 1751-0759

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