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Table 6 Hormone therapy (HT) and psychological adjustment

From: Psychological adjustment of men with prostate cancer: a review of the literature



Characteristics of the sample

Major Findings

Herr et al. (2000)

• Comparison of men treated with HT and men who defer such HT over 12 months

• EORTC – Prostate

• 144 patients with locally advanced PCA or PSA – relapse after surgery or radiotherapy

• Men on HT had significantly more fatigue, anergia and emotional distress then men who deferred HT

Herr et al. (1993)

• Men choosing or postponing HT followed up for 6 months

• EORTC – Prostate

• 35 patients with metastatic PCA

• Men on HT had more fatigue, psychological distress and sexual difficulties than those not on HT

da Silva et al. (1996)

• QOL (constructed by authors) examined in men on HT followed up for 12 months, rated by both patients and their physicians

• 63 patients with newly diagnosed PCA

• Poor correlation between the 2 sets of ratings

• Fatigue, and emotional and social functioning, did not improve with HT

Green (2002)

• Study of QOL in PCA patient and control subjects over 6 months

• Measures included EORTC and COPE Coping Scale

• 65 patients with non-localised PCA randomized to one of 3 forms of HT

• 16 controls

• Emotional distress, self-efficacy and coping at baseline similar in treated and control groups

• HT patients worse or better in various domains of QOL suggesting complex links

• Overall, groups did not differ over time in psychological functioning

Stone et al. (2000)

• Sample followed up for 3 months after HT with focus on fatigue

• Measures included EORTC, Hospital Depression and Anxiety Scale and 2 fatigue scales

• 58 patients, convenience sample, most with early stage disease

• Majority had significantly increased fatigue but not due to psychological factors (as was the case at baseline); rather due to diminished muscle function

Pirl et al. (2002)

• Men receiving HT for an average 3.3 years surveyed for depression

• Measures included the Beck Depression and Fatigue Severity Scales

• 45 patients of whom 12 had metastatic disease.

• Major depression in 13%, 8 times the national rate in men

• Past history of depression a risk factor for depressive reaction