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Table 6 Hormone therapy (HT) and psychological adjustment

From: Psychological adjustment of men with prostate cancer: a review of the literature

Study Design Characteristics of the sample Major Findings
Herr et al. (2000) • Comparison of men treated with HT and men who defer such HT over 12 months
• EORTC – Prostate
• 144 patients with locally advanced PCA or PSA – relapse after surgery or radiotherapy • Men on HT had significantly more fatigue, anergia and emotional distress then men who deferred HT
Herr et al. (1993) • Men choosing or postponing HT followed up for 6 months
• EORTC – Prostate
• 35 patients with metastatic PCA • Men on HT had more fatigue, psychological distress and sexual difficulties than those not on HT
da Silva et al. (1996) • QOL (constructed by authors) examined in men on HT followed up for 12 months, rated by both patients and their physicians • 63 patients with newly diagnosed PCA • Poor correlation between the 2 sets of ratings
• Fatigue, and emotional and social functioning, did not improve with HT
Green (2002) • Study of QOL in PCA patient and control subjects over 6 months
• Measures included EORTC and COPE Coping Scale
• 65 patients with non-localised PCA randomized to one of 3 forms of HT
• 16 controls
• Emotional distress, self-efficacy and coping at baseline similar in treated and control groups
• HT patients worse or better in various domains of QOL suggesting complex links
• Overall, groups did not differ over time in psychological functioning
Stone et al. (2000) • Sample followed up for 3 months after HT with focus on fatigue
• Measures included EORTC, Hospital Depression and Anxiety Scale and 2 fatigue scales
• 58 patients, convenience sample, most with early stage disease • Majority had significantly increased fatigue but not due to psychological factors (as was the case at baseline); rather due to diminished muscle function
Pirl et al. (2002) • Men receiving HT for an average 3.3 years surveyed for depression
• Measures included the Beck Depression and Fatigue Severity Scales
• 45 patients of whom 12 had metastatic disease. • Major depression in 13%, 8 times the national rate in men
• Past history of depression a risk factor for depressive reaction